Copyright © 2023 Agarwal Laboratory
Publications
Damo, E., Rieder, P., Coban, I., Silva, R.L., Kirchhoff, F., Simonetti, M. and Agarwal, A. (2022).
Glial cells as target for antidepressants in neuropathic pain.
Neuroforum, 28(2), pp.85-94. PDF
Wang, J., Fröhlich, H., Torres, F.B., Silva, R.L., Poschet, G., Agarwal, A. and Rappold, G.A. (2022).
Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome.
Proceedings of the National Academy of Sciences, 119(8), p.e2112852119. PDF
Fiore, F., Dereddi, R.R., Alhalaseh, K., Coban, I., Harb, A. and Agarwal, A. (2022).
Norepinephrine regulates Ca2+ signals and fate of oligodendrocyte progenitor cells in the cortex.
bioRxiv, pp.2022-08. PDF
Lu, T.Y., Hanumaihgari, P., Hsu, E.T., Agarwal, A. and Bergles, D.E. (2022).
Norepinephrine enhances oligodendrocyte precursor cell calcium dynamics in the cerebral cortex during arousal.
bioRxiv, pp.2022-08. PDF
Streich, L., Boffi, J.C., Wang, L., Alhalaseh, K., Barbieri, M., Rehm, R., Deivasigamani, S., Gross, C.T., Agarwal, A. and Prevedel, R. (2021).
High-resolution structural and functional deep brain imaging using adaptive optics three-photon microscopy.
Nature methods, 18(10), pp.1253-1258. PDF
Khawaja, R.R., Agarwal, A., Fukaya, M., Jeong, H.K., Gross, S., Gonzalez-Fernandez, E., Soboloff, J., Bergles, D.E. and Kang, S.H. (2021).
GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration.
Cell reports, 35(7), p.109147. PDF
Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J.P., Petzold, G.C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A. and Allen, N.J., (2021).
Reactive astrocyte nomenclature, definitions, and future directions.
Nature Neuroscience, 24(3), pp.312-325. PDF
Ye, L., Orynbayev, M., Zhu, X., Lim, E.Y., Dereddi, R.R., Agarwal, A., Bergles, D.E., Bhat, Ye, L., Orynbayev, M., Zhu, X., Lim, E.Y., Dereddi, R.R., Agarwal, A., Bergles, D.E., Bhat, M.A. and Paukert, M., (2020).
Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release.
Nature communications, 11(1), p.6157.PDF
Yoo, S.W., Agarwal, A., Smith, M.D., Khuder, S.S., Baxi, E.G., Thomas, A.G., Rojas, C., Moniruzzaman, M., Slusher, B.S., Bergles, D.E. and Calabresi, P.A., (2020).
Inhibition of neutral sphingomyelinase 2 promotes remyelination.
Science Advances, 6(40), p.eaba5210. PDF
Semyanov, A., Henneberger, C., & Agarwal, A. (2020).
Making sense of astrocytic calcium signals—from acquisition to interpretation.
Nature Reviews Neuroscience, 21(10), 551-564. PDF
Venkatesh H.S., Morishita W., Geraghty A.C., Silverbush D., Gillespie S.M., Arzt M., Tam L.T., Espenel C., Ponnuswami A., Ni L., Woo P.J., Taylor K.R., Agarwal A., Regev A., Brang D., Vogel H., Hervey-Jumper S., Bergles D.E., Suvà M.L., Malenka R.C., Monje M. (2019)
Electrical and synaptic integration of glioma into neural circuits.
Nature Sep;573(7775):539-545. PDF
Venkataramani V., Tanev D.I., Strahle C., Studier-Fischer A., Fankhauser L., Kessler T., Körber C., Kardorff M., Ratliff M., Xie R., Horstmann H., Messer M., Paik S.P., Knabbe J., Sahm F., Kurz F.T., Acikgöz A.A., Herrmannsdörfer F., Agarwal A., Bergles D.E., Winkler F., Kuner T. et al., (2019)
Glutamatergic synaptic input to glioma cells drives brain tumour progression.
Nature Sep;573(7775):532-538. PDF
BEFORE 2019:
Larson V.A., Mironova Y., Vanderpool K.G., Waisman A., Rash J.E., Agarwal A.*, Bergles D.E*. (2018)
Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility.
Elife. Mar 29;7 (*shared corresponsding author). PDF
Agarwal, A., Wu,, P.H., Hughes, E.G., Fukaya, M. Tischfield, M.A., Langseth, A.J., Wirtz, D., Bergles,, D.E. (2017)
Transient opening of the mitochondrial permeability transition pore induces microdomain calcium transients in astrocyte processes. Neuron 93(3): 587-605 (See cover art). PDF
Goebbels, S., Wieser, G., Pieper, A., Spitzer, S., Weege, B., Yan, K., Edgar, J., Yagensky, O., Wichert, S., Agarwal, A., Karram, K., Rossner, M., Tessier-Lavigne M., Káradóttir, R., Nave, K.A. (2017)
A neuronal PIP3-dependent program of oligodendrocyte precursor recruitment and myelination.
Nature Neuroscience Jan;20(1):10-15. PDF
Perea, G., Gómez, R., Mederos, S., Covelo, A., Ballesteros, J.J., Schlosser, L., Hernández-Vivanco, A., Martín-Fernández, M., Quintana, R., Rayan, A., Díez, A., Fuenzalida, M., Agarwal, A., Bergles, D.E., Bettler, B., Manahan-Vaughan, D., Martín, E.D., Kirchhoff, F., Araque, A., (2016)
Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks.
eLife. Dec 24;5. pii: e20362. doi: 10.7554/eLife.20362. PDF
Kim, Y.S., Anderson, M., Park, K., Zheng, Q., Agarwal, A., Gong, C., Saijilafu, Young, L., He, S., LaVinka P.C., Zhou, F., Bergles, D.E., Hanani, M., Guan, Y., Spray, D.C., and Dong, X. (2016)
Coupled activation of primary sensory neurons contributes to chronic pain.
Neuron 91(5): 1085-96. PDF
Zhang-Hooks, Y., Agarwal, A., Mishina, M., Bergles, D.E. (2016)
NMDA receptors enhance spontaneous activity and promote neuronal survival in the developing cochlea.
Neuron 89(2): 337-50. PDF
Reichel, J.M., Bedenk ,B.T., Gassen, N.C., Hafner, K., Buram, S.A., Almeida-Correa, S., Genewsky, A., Dedic, N., Giesert, F., Agarwal, A., Nave, K-A., Rein, T., Czisch M., Deussing J.M., Wotjak C.T. (2016)
Beware of your Cre-ation: lacZ expression impairs neuronal integrity and hippocampus-dependent memory.
Hippocampus Apr 22, 10.1002/hipo.22601. PDF
Biesecker, K.R., Srienc, A.I., Shimoda, A.M., Agarwal, A., Bergles, D.E., Kofuji, P., Newman, E.A. (2016) Glial cell calcium signaling mediates capillary regulation of blood flow.
Journal of Neuroscience 36(36): 9435-45. PDF
Otsu, Y., Couchman, K., Lyons, D.G., Collot, M., Agarwal, A., Mallet, J-M., Pfrieger, F.W., Bergles, D.E., Charpak, S. (2015)
Calcium dynamics of astrocyte during neurovascular coupling.
Nature Neuroscience. 18(2): 210-8. PDF
Rosa, J.M., Bos, R.M., Sack, G.S., Fortuny, C., Agarwal, A., Bergles, D.E., Flannery, J.G., Feller, M.B. (2015)
Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
eLife 14.4:e09590. PDF
Wang, H.C., Lin, C.C., Cheung, R., Zhang-Hooks, Y., Agarwal, A., Ellis-Davies, G., Rock, J., Bergles, D.E. (2015)
Spontaneous activity of cochlear hair cells triggered by fluid secretion mechanism in adjacent support cells.
Cell 163(6): 1348-59. PDF
Agarwal, A., Zhang, M., Trembak-Duff, I., Unterbarnscheidt, T., Radyushkin, K., Dibaj, P., Martins de Souza, D., Boretius, S., Brzózka, M.M., Steffens, H., Berning, S., Teng, Z., Gummert, M., Tantra, M., Guest, P.C., Willig, K.I., Frahm, J., Hell, S.W., Bahn, S., Rossner, M.J., Nave, K.-A., Ehrenreich, H., Zhang, W., and Schwab, M.H. (2014)
Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity.
Cell Reports. 8(4): 1130-45. PDF
Issa, J.B., Haeffele, B.D., Agarwal, A., Bergles, D.E., Young, E.D., Yue, D.T. (2014)
Multiscale Optical Ca2+ Imaging of Tonal Organization in Mouse Auditory Cortex.
Neuron. 83(4): 944-59. PDF
Agarwal, A., Bergles, D.E. (2014)
Astrocyte morphology is controlled by neuron-derived FGF.
Neuron. 83(2): 255-7. PDF
Paukert, M*., Agarwal, A*., Cha, J., Doze, V.A., Kang, J.U., Bergles D.E. (2014)
Norepinephrine controls astroglial responsiveness to local circuit activity.
Neuron. 82(6): 1263-70 (*Equal contribution). PDF
Agarwal, A., Dibaj P., Kassmann C.M., Goebbels S., Nave, K.-A., and Schwab, M. H. (2012)
In vivo imaging and non-invasive ablation of pyramidal neurons in adult NEX-CreERT2 mice.
Cerebral Cortex. 22(7): 1473-86 (Highlighted as cover art). PDF
Brinkmann, B. G*., Agarwal, A.*, Sereda, M. W., Garratt, A.N., Müller, T., Wende, H., Nawaz, S., Humml, C., Velanac, V., Radyushkin, K., Goebbels, S., Fischer, T. M., Lai, C., Ehrenreich, H., Birchmeier, C., Schwab, M. H., and Nave, K.-A. (2008)
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Neuron. 59(4): 581-95. (*Equal contribution). PDF